The evil Professor Klon is back, not only to overthrow the Government but also to control the world's supply of fresh water through his ingenious plan, "Black Water". When our blue planet has only 72 hours before turning black, Cicakman comes to the rescue. But he is not only faced by Professor Klon's artistic hired assassin "Rrama", but also his old enemies, Ginger Boys, who have returned in a powerful spiritual form. As the situation starts taking a downward spiral, even a super hero needs help. And much to his surprise, help appears in the most unexpected forms, including Danny his demised best friend, a powerful feng shui master and an unlikely party. Apart from his heavy responsibilities to save the world, he is compelled to address and resolve his own personal dilemmas... "Hairi" vs. "Cicakman" ... his personal feelings towards Tania, who is seeking the true identity of Cicakman... and ultimately... to choose whether to sacrifice his own life to save Iman (Danny's blind sister).

Hairi et Danny travaillent tous les deux pour Klon Technologies à la recherche d’antidotes pour les différents virus qui agressent les habitants de la ville de Metrofulus. Alors qu’ils travaillaient sur l’éradication du virus 266, Hairi ingère accidentellement un lézard contaminé. Dès lors, il constate assez vite qu’il se met à disposer de capacités hors normes : une agilité et une force sur-humaine, la capacité de ramper sur les murs ainsi qu’une langue puissante et extensible. Cicakman le super heros est né!